{"id":619,"date":"2024-06-20T17:06:24","date_gmt":"2024-06-20T17:06:24","guid":{"rendered":"http:\/\/sleepandhypnosis.org\/research\/abstract-mkid-6\/"},"modified":"2024-06-20T17:06:24","modified_gmt":"2024-06-20T17:06:24","slug":"abstract-mkid-6","status":"publish","type":"page","link":"https:\/\/sleepandhypnosis.org\/research\/abstract-mkid-6\/","title":{"rendered":"Abstract Mkid 6"},"content":{"rendered":"
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\n Effects of Microinjections of Triazolam into Medial Preoptic Area on Sleep and Brain Temperature in Rats\n <\/div>\n
\n Thythy T. Pham, Wallace B. Mendelson\n <\/div>\n
Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology 1999;1(1):10-13<\/div>\n
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The effects of microinjection of triazolam into the medial preoptic area on sleep and brain<\/div>\n
temperature in rats. We have previously reported that microinjections of triazolam into the<\/div>\n
medial preoptic area (MPA) of the anterior hypothalamus have a potent hypnotic effect in the<\/div>\n
rat. It has not been clear whether this response is due to \u201cdirect\u201d effects on sleep-regulating<\/div>\n
structures or is secondary to drug-induced alterations in temperature. Previous studies<\/div>\n
found no evidence of drug-induced changes in core temperature, but the possibility<\/div>\n
remained open that alterations in brain temperature (Tbr) occurred. For this reason we have<\/div>\n
now examined the effects of triazolam microinjections into the MPA on sleep and Tbr in rats.<\/div>\n
Each animal received both vehicle and triazolam in random sequence, in studies separated<\/div>\n
by three days. As in earlier reports, triazolam 0.25 \u03bcg produced a potent hypnotic effect by<\/div>\n
significantly decreasing sleep latency and wake time after sleep onset while increasing<\/div>\n
NREM sleep. In contrast, Tbr changes were minimal. Tbr during the first and second hours<\/div>\n
following microinjection, and at the time of sleep onset, did not differ between the triazolam<\/div>\n
and vehicle treatments. In summary, there was little evidence to suggest that the hypnotic<\/div>\n
effect of triazolam microinjections into the MPA is mediated by drug-induced alterations in<\/div>\n
Tbr.<\/div>\n<\/p><\/div>\n
\n Keywords:<\/b>
\n triazolam, benzodiazepines, sleep, thermoregulation\n <\/div>\n
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SUBMIT YOUR MANUSCRIPT Register Author Login Reviewer Login \u00a9 Copyright Transfer Form Effects of Microinjections of Triazolam into Medial Preoptic Area on Sleep and Brain Temperature in Rats Thythy T. Pham, Wallace B. Mendelson Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology 1999;1(1):10-13 The effects of microinjection of triazolam into the medial preoptic […]<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template_3.php","meta":{"om_disable_all_campaigns":false,"footnotes":""},"class_list":["post-619","page","type-page","status-publish","hentry","post-wrapper","thrv_wrapper"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages\/619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/types\/page"}],"replies":[{"embeddable":true,"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/comments?post=619"}],"version-history":[{"count":0,"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages\/619\/revisions"}],"wp:attachment":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/media?parent=619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}