{"id":600,"date":"2024-06-20T17:06:23","date_gmt":"2024-06-20T17:06:23","guid":{"rendered":"http:\/\/sleepandhypnosis.org\/research\/abstract-mkid-42\/"},"modified":"2024-06-20T17:06:23","modified_gmt":"2024-06-20T17:06:23","slug":"abstract-mkid-42","status":"publish","type":"page","link":"https:\/\/sleepandhypnosis.org\/research\/abstract-mkid-42\/","title":{"rendered":"Abstract Mkid 42"},"content":{"rendered":"
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\n Reduced Glutathione Regulates Sleep in Unrestrained Rats by Producing Oxidized Glutathione\n <\/div>\n
\n Kazuki Honda, Masami Sagara, Masayuki Ikeda, Shojiro Inou\n <\/div>\n
Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology 2000;2(1):26-30<\/div>\n
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\n The present study was conducted to examine whether reduced glutathione (GSH), a naturally occurring tripeptide in the brain, exert somnogenic activity in freely behaving rats, since its dimer oxidized glutathione (GSSG) is a potent endogenous sleeppromoting substance. Nocturnal 10-h intracerebroventricular (icv) infusion of 50 nmol GSH increased amount of non-rapid-eye-movement (nonREM) sleep during the 12-h dark period (maximally 21 % above the baseline). Dose-response relations exhibited a bell shape at 4 different doses in a range 10-100 nmol. However, inhibition of GSH biosynthesis by diurnal 10-h icv infusion of a GSH peroxidase inhibitor, N-ethylmaleimide (NEM), at 4 different doses in a range 0.01-10 mol, dose-dependently brought about suppression of both nonREM and REM sleep. These results indicate that GSSG biosynthesized from GSH is actually responsible for the GSH-induced enhancement of sleep.\n <\/div>\n
\n Keywords:<\/b>
\n glutathione, GSH peroxidase inhibitor, intracerebroventricular infusion,
\nN-ethylmaleimide, neuronal detoxification, nonREM sleep, sleep-promoting substance\n <\/div>\n
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SUBMIT YOUR MANUSCRIPT Register Author Login Reviewer Login \u00a9 Copyright Transfer Form Reduced Glutathione Regulates Sleep in Unrestrained Rats by Producing Oxidized Glutathione Kazuki Honda, Masami Sagara, Masayuki Ikeda, Shojiro Inou Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology 2000;2(1):26-30 The present study was conducted to examine whether reduced glutathione (GSH), a naturally […]<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template_3.php","meta":{"om_disable_all_campaigns":false,"footnotes":""},"class_list":["post-600","page","type-page","status-publish","hentry","post-wrapper","thrv_wrapper"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages\/600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/types\/page"}],"replies":[{"embeddable":true,"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/comments?post=600"}],"version-history":[{"count":0,"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages\/600\/revisions"}],"wp:attachment":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/media?parent=600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}