{"id":594,"date":"2024-06-20T17:06:22","date_gmt":"2024-06-20T17:06:22","guid":{"rendered":"http:\/\/sleepandhypnosis.org\/research\/abstract-mkid-37\/"},"modified":"2024-06-20T17:06:22","modified_gmt":"2024-06-20T17:06:22","slug":"abstract-mkid-37","status":"publish","type":"page","link":"https:\/\/sleepandhypnosis.org\/research\/abstract-mkid-37\/","title":{"rendered":"Abstract Mkid 37"},"content":{"rendered":"
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\n The Effects of Fluoxetine on Quantitative Sleep EEG in Depressed Outpatients\n <\/div>\n
\n Robert F. Hoffmann, Roseanne Armitage, Madhukar H. Trivedi, A. John Rush\n <\/div>\n
Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology 1999;1(4):217-224<\/div>\n
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\n In previous studies, fluoxetine has been shown to increase light, nonrestorative sleep and
\nto decrease sleep efficiency. This work also suggested that women are more sensitive to
\nthe alerting effects of selective serotonin reuptake inhibitors on sleep characteristics. The
\npurpose of the present study was to evaluate the effects of fluoxetine on quantitative
\nsleep EEG. The effects of five and ten weeks of fluoxetine treatment on quantitative sleep
\nEEG were evaluated in 36 patients with major depressive disorders compared to baseline
\nwhen patients were symptomatic but unmedicated. All patients were treatment
\nresponders, achieving symptom remission at week 10. Fluoxetine significantly increased
\nfast-frequency activity and decreased delta during sleep at both 5 weeks and 10 weeks
\nof treatment. Contrary to our expectation, treatment effects on EEG were not stronger in
\ndepressed women than men. The protocol also included sleep studies at week 30 of
\ntreatment and 7-8 weeks after medication discontinuation. Since only 13\/36 (36.1%)
\npatients completed the entire protocol, the effects of fluoxetine on quantitative sleep EEG
\nwere compared in study completers versus dropouts. Dropouts showed the largest
\nfluoxetine-induced EEG changes (from baseline to week 10) with greater beta amplitude
\nand lower delta amplitude than study completers. This effect approached significance. It
\nwas concluded that fluoxetine is alerting to both standard sleep measure and to
\nquantitative sleep EEG and that these effects may be related to clinical outcome.\n <\/div>\n
\n Keywords:<\/b>
\n fluoxetine, depression, sleep EEG\n <\/div>\n
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SUBMIT YOUR MANUSCRIPT Register Author Login Reviewer Login \u00a9 Copyright Transfer Form The Effects of Fluoxetine on Quantitative Sleep EEG in Depressed Outpatients Robert F. Hoffmann, Roseanne Armitage, Madhukar H. Trivedi, A. John Rush Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology 1999;1(4):217-224 In previous studies, fluoxetine has been shown to increase light, […]<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template_3.php","meta":{"om_disable_all_campaigns":false,"footnotes":""},"class_list":["post-594","page","type-page","status-publish","hentry","post-wrapper","thrv_wrapper"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages\/594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/types\/page"}],"replies":[{"embeddable":true,"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/comments?post=594"}],"version-history":[{"count":0,"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/pages\/594\/revisions"}],"wp:attachment":[{"href":"https:\/\/sleepandhypnosis.org\/research\/wp-json\/wp\/v2\/media?parent=594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}