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Exploring Gene Expression in Sleep, Dreams and
Hypnosis with the New DNA Microarray Technology:
A Call for Clinical-Experimental Research
Ernest Lawrence Rossi, Ph.D.
Sleep, dream, hypnosis and awake states are generally recognized as a continuum of
dynamical processes of the organism but current research has not resolved fundamen-tal
issues of how this continuum is to be explored. Recently the concept of Behavior Sta-te-
Related Gene Expression has been introduced to describe how psychobiological sta-tes
of awake, sleep, dreaming, arousal, novelty, environmental enrichment, physical exer-cise
and stress are associated with different patterns of gene expression. New research
techniques are emerging from The Human Genome Research Project that can be used
to identify patterns of gene expression in such behavioral states of the organism on the
cellular-genetic level. Current research developments in DNA Microarray Technology that
are being used to rapidly assess gene expression in the various states of health and di-sease
are discussed as a new approach to characterize the psychobiology of the cell
cycle, arousal, stress, sleep, dream and the possible therapeutic applications of hypno-sis.
(Sleep and Hypnosis 2000;1:40-46)
Keywords: sleep, dreams, therapeutic hypnosis, consciousness, memory, learning, novelty,
psychobiology, behavior state-related gene expression, gene chip microarrays, DNA array
technology. |
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