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Sleep-Wake Disturbances in Fibromyalgia
Mehmet Yücel Agargun M.D
Fibromyalgia characterized unrefreshing sleep, sleep physiological disturbances,
depressed mood, and cognitive difficulties in addition to widespread pain, persisting for
at least 3 months, and a minimum of 11 of 18 tender points, tenderness, and other
somatic symptoms. Among polysomnographic abnormalities, the most common finding
is the intrusion of alpha rhythm into NREM sleep (alpha-delta sleep). Patients with
fibromyalgia also exhibit prolonged sleep onset latencies, an increased number of
arousals, and increases in stage 1 sleep. However, alpha-delta sleep is not specific or
pathognomonic for the diagnosis of fibromyalgia and may represent an epiphenomenon
of an undefined central nervous system disturbance. A strong relationship between sleep
disturbance and pain perception is clear in fibromyalgia. The interactions among immune
system, pain, and sleep disturbance and therapeutic implications are discussed in this
article. (Sleep and Hypnosis 2002;4(3):93-105)
| Keywords: fibromyalgia, sleep disturbance, alpha-delta sleep, pain, immune system |
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