The Effect of Donepezil on Sleep in Patients With Alzheimer’s Disease: An Open Pilot Study
Michael Schredl, Silvia Speck
Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology 2005;7(2):47-51
Previous research has shown that acetylcholinesterase inhibitors may enhance REM sleep. The present pilot study indicates that donepezil also exerts a marked effect on REM sleep parameters in patients with Alzheimer’s disease: REM density and duration of the first REM period were increased whereas REM latency was reduced. It will be interesting to study whether the donepezil effect on REM sleep is predictive of the therapeutic efficiency of the drug.
Keywords:
Donepezil, REM sleep, Alzheimer’s disease
Donepezil, REM sleep, Alzheimer’s disease
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